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v-sis Oncogene-induced transformation of human fibroblasts into cells capable of forming benign tumorsDAJUN YANG; KOHLER, S. K; MAHER, V. M et al.Carcinogenesis (New York. Print). 1994, Vol 15, Num 10, pp 2167-2175, issn 0143-3334Article

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Macrocyclization in the design of a conformationally constrained Grb2 SH2 domain inhibitorYANG GAO; VOIGT, Johannes; WU, Jane X et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 14, pp 1889-1892, issn 0960-894XArticle

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